Forkhead O deficiency effect on hematopoietic stem cells
Summary:
Analysis of lineage-negative Sca-1+, c-Kit+ (LSK) cells lacking the Forkhead O transcription factors FoxO1, FoxO3, and FoxO4. The LSK cell population is enriched for hematopoietic stem cells (HSCs). Results provide insight into the role of FoxO family members in hematopoiesis.
Tothova Z, Kollipara R, Huntly BJ, Lee BH et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007 Jan 26;128(2):325-39. PMID: 17254970
