Antipsychotic agents clozapine and haloperidol effects on the brain (II)
Summary:
Analysis of brains of animals treated for 12 weeks with the atypical antipsychotic clozapine or the typical antipsychotic haloperidol. Clozapine's use as an antipsychotic is limited by agranulocytosis. Results provide insight into the molecular basis of clozapine's therapeutic and toxic effects.
Rizig MA, McQuillin A, Ng A, Robinson M et al. A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia. J Psychopharmacol 2012 Sep;26(9):1218-30. PMID: 22767372
