Thioredoxin interacting protein mutant model of hepatocellular carcinoma
Summary:
Analysis of hepatocellular carcinoma (HCC) tumors from thioredoxin interacting protein (Txnip) deficient mutants. Txnip deficiency leads to HCC in mice. Results provide insight into the role of Txnip in the pathogenesis of HCC.
Sheth SS, Bodnar JS, Ghazalpour A, Thipphavong CK et al. Hepatocellular carcinoma in Txnip-deficient mice. Oncogene 2006 Jun 15;25(25):3528-36. PMID: 16607285