Interferon-gamma tolerogenic effect on CD8+ dendritic cells
Summary:
Analysis of splenic CD8+ dendritic cells (DCs) rendered tolerogenic by interferon (IFN)-γ, which activates indoleamine 2,3-dioxygenase (IDO) thereby initiating immunosuppression. Results suggest the IDO-dependent tolerogenic program requires tight co-modulation of a very restricted set of genes.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Orabona C, Puccetti P, Vacca C, Bicciato S et al. Toward the identification of a tolerogenic signature in IDO-competent dendritic cells. Blood 2006 Apr 1;107(7):2846-54. PMID: 16339401
