Analysis of liver in two NADPH-cytochrome P450 reductase (CPR)-loss transgenic models: liver-Cpr-null (liver-specific Cpr deletion) and Cpr-low (global Cpr suppression). Results provide insight into potential mechanisms underlying altered hepatic gene expression related to CPR-deficiency.
Weng Y, DiRusso CC, Reilly AA, Black PN et al. Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. J Biol Chem 2005 Sep 9;280(36):31686-98. PMID: 16006652
