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Year Number of Results
1980 1
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1995 3
1998 1
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2003 2
2006 1
2010 1
2011 1
2014 1
2015 3
2016 2
2017 1
2018 3
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2022 1
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Page 1
Gene therapy for RPE65-related retinal disease.
Miraldi Utz V, Coussa RG, Antaki F, Traboulsi EI. Miraldi Utz V, et al. Ophthalmic Genet. 2018 Dec;39(6):671-677. doi: 10.1080/13816810.2018.1533027. Epub 2018 Oct 18. Ophthalmic Genet. 2018. PMID: 30335549 Review.
Of the large number genes that cause IRDs, bi-allelic mutations in RPE65 lead to Leber Congenital Amaurosis type 2 (LCA 2), and can also result in phenotypes described as severe early childhood onset retinal dystrophy (SECORD) and Retinitis pigmentosa 20 (RP20). Fol …
Of the large number genes that cause IRDs, bi-allelic mutations in RPE65 lead to Leber Congenital Amaurosis type 2 (LCA 2), and can also res …
Retinitis pigmentosa: genes, proteins and prospects.
Hims MM, Diager SP, Inglehearn CF. Hims MM, et al. Dev Ophthalmol. 2003;37:109-25. doi: 10.1159/000072042. Dev Ophthalmol. 2003. PMID: 12876833 Review.
The name retinitis pigmentosa (RP) describes a heterogeneous group of inherited progressive retinal dystrophies, primarily affecting the peripheral retina. ...RP can be inherited in autosomal dominant, autosomal recessive, X-linked, mitochondrial and genetically mor …
The name retinitis pigmentosa (RP) describes a heterogeneous group of inherited progressive retinal dystrophies, primarily aff …
Therapeutic Potential of Co-enzyme Q10 in Retinal Diseases.
Zhang X, Tohari AM, Marcheggiani F, Zhou X, Reilly J, Tiano L, Shu X. Zhang X, et al. Curr Med Chem. 2017;24(39):4329-4339. doi: 10.2174/0929867324666170801100516. Curr Med Chem. 2017. PMID: 28762311 Review.
Since oxidative stress also plays a critical role in the pathogenesis of diabetic retinopathy and retinitis pigmentosa, CoQ10 is a therapeutic target for both conditions. ...
Since oxidative stress also plays a critical role in the pathogenesis of diabetic retinopathy and retinitis pigmentosa, CoQ10 …
Therapeutic potential of curcumin in major retinal pathologies.
Peddada KV, Brown A, Verma V, Nebbioso M. Peddada KV, et al. Int Ophthalmol. 2019 Mar;39(3):725-734. doi: 10.1007/s10792-018-0845-y. Epub 2018 Feb 5. Int Ophthalmol. 2019. PMID: 29404861 Review.
RESULTS: Curcumin has found a role in slowing, and in some cases even reversing, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, proliferative vitreoretinopathy, and retinal cancers. ...
RESULTS: Curcumin has found a role in slowing, and in some cases even reversing, age-related macular degeneration, diabetic retinopathy, …
Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration.
Berner AK, Kleinman ME. Berner AK, et al. Adv Exp Med Biol. 2016;854:39-44. doi: 10.1007/978-3-319-17121-0_6. Adv Exp Med Biol. 2016. PMID: 26427391 Free PMC article. Review.
In the field of ocular biology, there are data to suggest that HDAC inhibition may suppress neovascularization and may be a possible treatment for retinitis pigmentosa and dry age-related macular degeneration (AMD). ...
In the field of ocular biology, there are data to suggest that HDAC inhibition may suppress neovascularization and may be a possible treatme …
Cell therapy for retinal degenerative disorders: a systematic review and three-level meta-analysis.
Khaboushan AS, Ebadpour N, Moghadam MMJ, Rezaee Z, Kajbafzadeh AM, Zolbin MM. Khaboushan AS, et al. J Transl Med. 2024 Mar 2;22(1):227. doi: 10.1186/s12967-024-05016-x. J Transl Med. 2024. PMID: 38431596 Free PMC article. Review.
This meta-analysis aims to comprehensively evaluate the efficacy of cell therapy in treating age-related macular degeneration (AMD), retinitis pigmentosa (RP), and Stargardt macular degeneration (SMD) as the most prevalent RDDs. ...RESULTS: Overall, 8345 studies wer …
This meta-analysis aims to comprehensively evaluate the efficacy of cell therapy in treating age-related macular degeneration (AMD), reti …
Epidemiology of Mutations in the 65-kDa Retinal Pigment Epithelium (RPE65) Gene-Mediated Inherited Retinal Dystrophies: A Systematic Literature Review.
Sallum JMF, Kaur VP, Shaikh J, Banhazi J, Spera C, Aouadj C, Viriato D, Fischer MD. Sallum JMF, et al. Adv Ther. 2022 Mar;39(3):1179-1198. doi: 10.1007/s12325-021-02036-7. Epub 2022 Jan 30. Adv Ther. 2022. PMID: 35098484 Free PMC article. Review.
Adult and paediatric patients with vision loss due to IRD caused by biallelic mutations in the 65-kDa retinal pigment epithelium (RPE65) gene are often clinically diagnosed as retinitis pigmentosa (RP), and Leber congenital amaurosis (LCA). This study aimed to under …
Adult and paediatric patients with vision loss due to IRD caused by biallelic mutations in the 65-kDa retinal pigment epithelium (RPE65) gen …
Gene therapy in inherited retinal degenerative diseases, a review.
Takahashi VKL, Takiuti JT, Jauregui R, Tsang SH. Takahashi VKL, et al. Ophthalmic Genet. 2018 Oct;39(5):560-568. doi: 10.1080/13816810.2018.1495745. Epub 2018 Jul 24. Ophthalmic Genet. 2018. PMID: 30040511 Review.
Retinal degenerations encompass multifactorial diseases such as age-related macular degeneration, Leber congenital amaurosis, Stargardt disease, and retinitis pigmentosa. Although there is currently no cure for degenerative retinal diseases, ophthalmology has been a …
Retinal degenerations encompass multifactorial diseases such as age-related macular degeneration, Leber congenital amaurosis, Stargardt dise …
Molecular diagnostics of genetic eye diseases.
Fan BJ, Tam PO, Choy KW, Wang DY, Lam DS, Pang CP. Fan BJ, et al. Clin Biochem. 2006 Mar;39(3):231-9. doi: 10.1016/j.clinbiochem.2005.11.010. Epub 2006 Jan 10. Clin Biochem. 2006. PMID: 16412407 Review.
The three common genetic eye diseases, primary open angle glaucoma, age-related macular degeneration, and retinitis pigmentosa, all have known gene mutations, but these account for only a portion of the patients. ...
The three common genetic eye diseases, primary open angle glaucoma, age-related macular degeneration, and retinitis pigmentosa …
25 results