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PubMed (cited) for id: 609791

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Biallelic variants in LINGO1 are associated with autosomal recessive intellectual disability, microcephaly, speech and motor delay.
Ansar M, Riazuddin S, Sarwar MT, Makrythanasis P, Paracha SA, Iqbal Z, Khan J, Assir MZ, Hussain M, Razzaq A, Polla DL, Taj AS, Holmgren A, Batool N, Misceo D, Iwaszkiewicz J, de Brouwer APM, Guipponi M, Hanquinet S, Zoete V, Santoni FA, Frengen E, Ahmed J, Riazuddin S, van Bokhoven H, Antonarakis SE. Ansar M, et al. Genet Med. 2018 Jul;20(7):778-784. doi: 10.1038/gim.2017.113. Epub 2017 Aug 24. Genet Med. 2018. PMID: 28837161 Free article.
Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O. Inoue H, et al. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14430-5. doi: 10.1073/pnas.0700901104. Epub 2007 Aug 28. Proc Natl Acad Sci U S A. 2007. PMID: 17726113 Free PMC article.
LINGO-1 negatively regulates myelination by oligodendrocytes.
Mi S, Miller RH, Lee X, Scott ML, Shulag-Morskaya S, Shao Z, Chang J, Thill G, Levesque M, Zhang M, Hession C, Sah D, Trapp B, He Z, Jung V, McCoy JM, Pepinsky RB. Mi S, et al. Nat Neurosci. 2005 Jun;8(6):745-51. doi: 10.1038/nn1460. Epub 2005 May 15. Nat Neurosci. 2005. PMID: 15895088
LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.
Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, Allaire N, Perrin S, Sands B, Crowell T, Cate RL, McCoy JM, Pepinsky RB. Mi S, et al. Nat Neurosci. 2004 Mar;7(3):221-8. doi: 10.1038/nn1188. Epub 2004 Feb 15. Nat Neurosci. 2004. PMID: 14966521