Abstract
Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.
MeSH terms
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Animals
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Binding Sites
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Carnitine / analogs & derivatives
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Carnitine / chemistry
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Carnitine O-Palmitoyltransferase / chemistry*
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Carnitine O-Palmitoyltransferase / metabolism
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Catalysis
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Cell Membrane / chemistry*
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Coenzyme A / chemistry
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Crystallography, X-Ray
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Escherichia coli / metabolism
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Fatty Acids / metabolism
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Lipid Bilayers / chemistry
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Molecular Conformation
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Protein Binding
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Protein Conformation
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Protein Structure, Tertiary
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Rats
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Recombinant Proteins / chemistry
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Solubility
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Substrate Specificity
Substances
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Fatty Acids
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Lipid Bilayers
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Recombinant Proteins
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acylcarnitine
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Carnitine O-Palmitoyltransferase
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Carnitine
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Coenzyme A