A monotopic membrane protein goes solo

Structure. 2006 Apr;14(4):628-9. doi: 10.1016/j.str.2006.03.002.

Abstract

Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Binding Sites
  • Carnitine / analogs & derivatives
  • Carnitine / chemistry
  • Carnitine O-Palmitoyltransferase / chemistry*
  • Carnitine O-Palmitoyltransferase / metabolism
  • Catalysis
  • Cell Membrane / chemistry*
  • Coenzyme A / chemistry
  • Crystallography, X-Ray
  • Escherichia coli / metabolism
  • Fatty Acids / metabolism
  • Lipid Bilayers / chemistry
  • Molecular Conformation
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary
  • Rats
  • Recombinant Proteins / chemistry
  • Solubility
  • Substrate Specificity

Substances

  • Fatty Acids
  • Lipid Bilayers
  • Recombinant Proteins
  • acylcarnitine
  • Carnitine O-Palmitoyltransferase
  • Carnitine
  • Coenzyme A