Abstract
The cDNA sequence coding for the cGMP-gated cation channel expressed in the mouse kidney inner medullary collecting duct has been determined. The kidney cGMP-gated cation channel cDNA has an open reading frame of 2055 nucleotides and encodes a 685 amino acid protein. One cDNA clone is alternatively spliced thereby producing a deletion of 107 bp. Two differentially spliced 5' untranslated regions were determined by 5' RACE.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Line
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Cloning, Molecular
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Cyclic GMP / metabolism*
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Cyclic Nucleotide-Gated Cation Channels
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Ion Channels / antagonists & inhibitors
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Ion Channels / biosynthesis*
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Ion Channels / chemistry
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Kidney Medulla / metabolism*
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Kidney Tubules, Collecting / metabolism*
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Mice
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Molecular Sequence Data
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Rod Cell Outer Segment / metabolism
Substances
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Cyclic Nucleotide-Gated Cation Channels
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Ion Channels
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Cyclic GMP
Associated data
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GENBANK/U19715
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GENBANK/U19716
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GENBANK/U19717