PubMed for id: 25090576

Year	Number of Results
1998	3
2002	1
2004	2
2007	2
2008	1
2009	1
2010	1
2013	1
2014	2
2018	3
2019	3
2020	1
2021	2
2024	0

1

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.

Lee S, Karki R, Wang Y, Nguyen LN, Kalathur RC, Kanneganti TD. Lee S, et al. Nature. 2021 Sep;597(7876):415-419. doi: 10.1038/s41586-021-03875-8. Epub 2021 Sep 1. Nature. 2021. PMID: 34471287 Free PMC article.

2

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1.

Muendlein HI, Connolly WM, Magri Z, Smirnova I, Ilyukha V, Gautam A, Degterev A, Poltorak A. Muendlein HI, et al. Nat Commun. 2021 Jan 4;12(1):86. doi: 10.1038/s41467-020-20357-z. Nat Commun. 2021. PMID: 33397971 Free PMC article.

3

Integration of innate immune signalling by caspase-8 cleavage of N4BP1.

Gitlin AD, Heger K, Schubert AF, Reja R, Yan D, Pham VC, Suto E, Zhang J, Kwon YC, Freund EC, Kang J, Pham A, Caothien R, Bacarro N, Hinkle T, Xu M, McKenzie BS, Haley B, Lee WP, Lill JR, Roose-Girma M, Dohse M, Webster JD, Newton K, Dixit VM. Gitlin AD, et al. Nature. 2020 Nov;587(7833):275-280. doi: 10.1038/s41586-020-2796-5. Epub 2020 Sep 24. Nature. 2020. PMID: 32971525

4

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.

Fritsch M, Günther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, Schiffmann LM, Stair N, Stocks H, Seeger JM, Lamkanfi M, Krönke M, Pasparakis M, Kashkar H. Fritsch M, et al. Nature. 2019 Nov;575(7784):683-687. doi: 10.1038/s41586-019-1770-6. Epub 2019 Nov 20. Nature. 2019. PMID: 31748744

5

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation.

Tang Y, Tu H, Zhang J, Zhao X, Wang Y, Qin J, Lin X. Tang Y, et al. Nat Commun. 2019 Sep 13;10(1):4157. doi: 10.1038/s41467-019-12033-8. Nat Commun. 2019. PMID: 31519887 Free PMC article.

6

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.

Newton K, Wickliffe KE, Dugger DL, Maltzman A, Roose-Girma M, Dohse M, Kőműves L, Webster JD, Dixit VM. Newton K, et al. Nature. 2019 Oct;574(7778):428-431. doi: 10.1038/s41586-019-1548-x. Epub 2019 Sep 11. Nature. 2019. PMID: 31511692

7

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.

Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY, Rongvaux A, Bunnell SC, Shao F, Green DR, Poltorak A. Sarhan J, et al. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10888-E10897. doi: 10.1073/pnas.1809548115. Epub 2018 Oct 31. Proc Natl Acad Sci U S A. 2018. PMID: 30381458 Free PMC article.

8

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E. Orning P, et al. Science. 2018 Nov 30;362(6418):1064-1069. doi: 10.1126/science.aau2818. Epub 2018 Oct 25. Science. 2018. PMID: 30361383 Free PMC article.

9

Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis.

Meng H, Liu Z, Li X, Wang H, Jin T, Wu G, Shan B, Christofferson DE, Qi C, Yu Q, Li Y, Yuan J. Meng H, et al. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2001-E2009. doi: 10.1073/pnas.1722013115. Epub 2018 Feb 12. Proc Natl Acad Sci U S A. 2018. PMID: 29440439 Free PMC article.

10

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.

Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong YN, Janke LJ, Kelliher MA, Kanneganti TD, Green DR. Dillon CP, et al. Cell. 2014 May 22;157(5):1189-202. doi: 10.1016/j.cell.2014.04.018. Epub 2014 May 8. Cell. 2014. PMID: 24813850 Free PMC article.

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