First Complete Genome Sequence of the Dutch Veterinary Coxiella burnetii Strain NL3262, Originating from the Largest Global Q Fever Outbreak, and Draft Genome Sequence of Its Epidemiologically Linked Chronic Human Isolate NLhu3345937

Runa Kuley; Hilde E Smith; Ingmar Janse; Frank L Harders; Frank Baas; Elio Schijlen; Marrigje H Nabuurs-Franssen; Mari A Smits; Hendrik I J Roest; Alex Bossers

doi:10.1128/genomeA.00245-16

First Complete Genome Sequence of the Dutch Veterinary Coxiella burnetii Strain NL3262, Originating from the Largest Global Q Fever Outbreak, and Draft Genome Sequence of Its Epidemiologically Linked Chronic Human Isolate NLhu3345937

Genome Announc. 2016 Apr 21;4(2):e00245-16. doi: 10.1128/genomeA.00245-16.

Authors

Affiliations

¹ Department of Infection Biology, Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands Host Microbe Interactomics, Wageningen University, Wageningen, The Netherlands.
² Department of Infection Biology, Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands.
³ National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
⁴ Department of Genome Analysis, Amsterdam Medical Centre, Amsterdam, The Netherlands.
⁵ Department of Bioscience, Plant Research International, part of Wageningen UR, Wageningen, The Netherlands.
⁶ Department of Medical Microbiology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
⁷ Department of Bacteriology and Epidemiology, Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands.
⁸ Department of Infection Biology, Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands alex.bossers@wur.nl.

Abstract

The largest global Q fever outbreak occurred in The Netherlands during 2007 to 2010. Goats and sheep were identified as the major sources of disease. Here, we report the first complete genome sequence of ITALIC! Coxiella burnetiigoat outbreak strain NL3262 and that of an epidemiologically linked chronic human strain, both having the outbreak-related ITALIC! CbNL01multilocus variable-number tandem-repeat analysis (MLVA) genotype.

Grants and funding

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.