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Cytochromes P450 2C8 and 3A Catalyze the Metabolic Activation of the Tyrosine Kinase Inhibitor Masitinib.

Latham BD, Oskin DS, Crouch RD, Vergne MJ, Jackson KD. Latham BD, et al. Chem Res Toxicol. 2022 Sep 19;35(9):1467-1481. doi: 10.1021/acs.chemrestox.2c00057. Epub 2022 Sep 1. Chem Res Toxicol. 2022. PMID: 36048877 Free PMC article.

Comparative multi-species analysis of potassium cyanide toxicity.

Tez S, Oral R, Koçbaş F, Koru E, Türkçü N, Pagano G, Trifuoggi M. Tez S, et al. Mar Pollut Bull. 2022 Sep;182:113965. doi: 10.1016/j.marpolbul.2022.113965. Epub 2022 Jul 22. Mar Pollut Bull. 2022. PMID: 35872477 No abstract available.

Neuroprotective flavonoids of the leaf of Antiaris africana Englea against cyanide toxicity.

Ilesanmi OB, Akinmoladun AC, Elusiyan CA, Ogungbe IV, Olugbade TA, Olaleye MT. Ilesanmi OB, et al. J Ethnopharmacol. 2022 Jan 10;282:114592. doi: 10.1016/j.jep.2021.114592. Epub 2021 Sep 1. J Ethnopharmacol. 2022. PMID: 34480996

A novel aqueous dimethyl trisulfide formulation is effective at low doses against cyanide toxicity in non-anesthetized mice and rats.

Lippner DS, Hildenberger DM, Rhoomes MO, Winborn JN, Dixon H, McDonough J, Rockwood GA. Lippner DS, et al. Clin Toxicol (Phila). 2022 Jan;60(1):83-94. doi: 10.1080/15563650.2021.1935991. Epub 2021 Jul 5. Clin Toxicol (Phila). 2022. PMID: 34219566

Evaluation of aqueous dimethyl trisulfide as an antidote to a highly lethal cyanide poisoning in a large swine model.

Hendry-Hofer TB, Severance CC, Bhadra S, Ng PC, Soules K, Lippner DS, Hildenberger DM, Rhoomes MO, Winborn JN, Logue BA, Rockwood GA, Bebarta VS. Hendry-Hofer TB, et al. Clin Toxicol (Phila). 2022 Jan;60(1):95-101. doi: 10.1080/15563650.2021.1935992. Epub 2021 Jun 18. Clin Toxicol (Phila). 2022. PMID: 34142637

Cyanide Poisoning Compromises Gene Pathways Modulating Cardiac Injury in Vivo.

Ma KH, Lippner DS, Basi KA, DeLeon SM, Cappuccio WR, Rhoomes MO, Hildenberger DM, Hoard-Fruchey HM, Rockwood GA. Ma KH, et al. Chem Res Toxicol. 2021 Jun 21;34(6):1530-1541. doi: 10.1021/acs.chemrestox.0c00467. Epub 2021 Apr 29. Chem Res Toxicol. 2021. PMID: 33914522

Hydroxocobalamin interference in routine laboratory tests: Development of a protocol for identifying samples and reporting results from patients treated with Cyanokit^TM.

Dang S, Tsui AK, Herndon R, Babiak C, Szkotak A, Füzéry AK, Raizman JE. Dang S, et al. Clin Biochem. 2021 May;91:31-38. doi: 10.1016/j.clinbiochem.2021.01.001. Epub 2021 Jan 12. Clin Biochem. 2021. PMID: 33444605 Clinical Trial.

Can isosorbide dinitrate oral spray serve as an immediate bridging therapy for a mass cyanide poisoning?

Lavon O, Rockwood GA, Eisenkraft A. Lavon O, et al. Clin Toxicol (Phila). 2021 Aug;59(8):734-739. doi: 10.1080/15563650.2020.1856382. Epub 2020 Dec 4. Clin Toxicol (Phila). 2021. PMID: 33274646

Activation of the carotid body increases directly recorded cardiac sympathetic nerve activity and coronary blood flow in conscious sheep.

Pachen M, Abukar Y, Shanks J, Lever N, Ramchandra R. Pachen M, et al. Am J Physiol Regul Integr Comp Physiol. 2021 Mar 1;320(3):R203-R212. doi: 10.1152/ajpregu.00246.2020. Epub 2020 Nov 18. Am J Physiol Regul Integr Comp Physiol. 2021. PMID: 33206558 Free article.

Carbon-13 synthesis and NMR spectroscopic geometric isomer evaluation to support the filing of teriflunomide.

Kurz M, Gretzke D, Hörlein R, Turpault S, Atzrodt J, Derdau V. Kurz M, et al. J Labelled Comp Radiopharm. 2021 Feb;64(2):82-88. doi: 10.1002/jlcr.3876. Epub 2020 Aug 31. J Labelled Comp Radiopharm. 2021. PMID: 32840004

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