PubMed (MeSH Keyword) for id: 71715374

Year	Number of Results
2017	2
2018	2
2019	1
2020	2
2021	6
2022	5
2023	2
2024	2

1

Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts.

Arakawa Y, Jo U, Kumar S, Sun NY, Elloumi F, Thomas A, Roper N, Varghese DG, Takebe N, Zhang X, Ceribelli M, Holland DO, Beck E, Itkin Z, McKnight C, Wilson KM, Travers J, Klumpp-Thomas C, Thomas CJ, Hoang CD, Hernandez JM, Del Rivero J, Pommier Y. Arakawa Y, et al. Cancer Res Commun. 2024 Mar 19;4(3):834-848. doi: 10.1158/2767-9764.CRC-24-0085. Cancer Res Commun. 2024. PMID: 38451783 Free PMC article.

2

The ubiquitin-proteasome pathway inhibitor TAK-243 has major effects on calcium handling in mammalian cells.

Gao X, Keller KR, Bonzerato CG, Li P, Laemmerhofer M, Wojcikiewicz RJH. Gao X, et al. Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119618. doi: 10.1016/j.bbamcr.2023.119618. Epub 2023 Oct 29. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 37907195

3

Proteasomal pathway inhibition as a potential therapy for NF2-associated meningioma and schwannoma.

Bhattacharyya S, Oblinger JL, Beauchamp RL, Yin Z, Erdin S, Koundinya P, Ware AD, Ferrer M, Jordan JT, Plotkin SR, Xu L, Chang LS, Ramesh V. Bhattacharyya S, et al. Neuro Oncol. 2023 Sep 5;25(9):1617-1630. doi: 10.1093/neuonc/noad037. Neuro Oncol. 2023. PMID: 36806881 Free PMC article.

4

Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes.

Barghout SH, Mann MK, Aman A, Yu Y, Alteen MG, Schimmer AD, Schapira M, Arrowsmith CH, Barsyte-Lovejoy D. Barghout SH, et al. ACS Chem Biol. 2022 Oct 21;17(10):2801-2816. doi: 10.1021/acschembio.2c00451. Epub 2022 Sep 9. ACS Chem Biol. 2022. PMID: 36084291

5

Targeting the E1 ubiquitin-activating enzyme (UBA1) improves elexacaftor/tezacaftor/ivacaftor efficacy towards F508del and rare misfolded CFTR mutants.

Borgo C, D'Amore C, Capurro V, Tomati V, Sondo E, Cresta F, Castellani C, Pedemonte N, Salvi M. Borgo C, et al. Cell Mol Life Sci. 2022 Mar 16;79(4):192. doi: 10.1007/s00018-022-04215-3. Cell Mol Life Sci. 2022. PMID: 35292885 Free PMC article.

6

Targeting the Ubiquitin-Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer.

Majeed S, Aparnathi MK, Nixon KCJ, Venkatasubramanian V, Rahman F, Song L, Weiss J, Barayan R, Sugumar V, Barghout SH, Pearson JD, Bremner R, Schimmer AD, Tsao MS, Liu G, Lok BH. Majeed S, et al. Clin Cancer Res. 2022 May 2;28(9):1966-1978. doi: 10.1158/1078-0432.CCR-21-0344. Clin Cancer Res. 2022. PMID: 35165102 Free PMC article.

7

ABCB1 limits the cytotoxic activity of TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1.

Wu Z, Yang Y, Lei Z, Narayanan S, Wang J, Teng Q, Murakami M, Ambudkar SV, Ping F, Chen Z. Wu Z, et al. Front Biosci (Landmark Ed). 2022 Jan 5;27(1):5. doi: 10.31083/j.fbl2701005. Front Biosci (Landmark Ed). 2022. PMID: 35090310 Free PMC article.

8

SUMOylation regulates the number and size of promyelocytic leukemia-nuclear bodies (PML-NBs) and arsenic perturbs SUMO dynamics on PML by insolubilizing PML in THP-1 cells.

Hirano S, Udagawa O. Hirano S, et al. Arch Toxicol. 2022 Feb;96(2):545-558. doi: 10.1007/s00204-021-03195-w. Epub 2022 Jan 10. Arch Toxicol. 2022. PMID: 35001170

9

E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor.

García-Valverde A, Rosell J, Sayols S, Gómez-Peregrina D, Pilco-Janeta DF, Olivares-Rivas I, de Álava E, Maurel J, Rubió-Casadevall J, Esteve A, Gut M, Valverde C, Barretina J, Carles J, Demetri GD, Fletcher JA, Arribas J, Serrano C. García-Valverde A, et al. Oncogene. 2021 Dec;40(48):6614-6626. doi: 10.1038/s41388-021-02049-0. Epub 2021 Oct 7. Oncogene. 2021. PMID: 34621020

10

GRP78 determines glioblastoma sensitivity to UBA1 inhibition-induced UPR signaling and cell death.

Liu G, Yu J, Wu R, Shi L, Zhang X, Zhang W, Zhong X, Wang Y, Li H, Shen Y, Wu C, Yu R, Niu M, Liu X. Liu G, et al. Cell Death Dis. 2021 Jul 23;12(8):733. doi: 10.1038/s41419-021-04023-w. Cell Death Dis. 2021. PMID: 34301924 Free PMC article. Retracted.

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