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PubMed (MeSH Keyword) for id: 24871823
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Lessons from (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial degeneration in rats.
J Med Chem. 2013 Sep 12;56(17):6651-65. doi: 10.1021/jm400926x. Epub 2013 Aug 29.
J Med Chem. 2013.
PMID: 23944843
A tyrosine kinase inhibitor-induced myocardial degeneration in rats through off-target phosphodiesterase inhibition.
Hu W, Hirakawa B, Jessen B, Lee M, Aguirre S.
Hu W, et al.
J Appl Toxicol. 2012 Dec;32(12):1008-20. doi: 10.1002/jat.2801. Epub 2012 Aug 31.
J Appl Toxicol. 2012.
PMID: 22936366
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Cardiovascular effects in rats following exposure to a receptor tyrosine kinase inhibitor.
Aguirre SA, Heyen JR, Collette W 3rd, Bobrowski W, Blasi ER.
Aguirre SA, et al.
Toxicol Pathol. 2010 Apr;38(3):416-28. doi: 10.1177/0192623310364027. Epub 2010 Mar 15.
Toxicol Pathol. 2010.
PMID: 20231546
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