(+/-)-4-tert-butyl-3-cyano-1-(4-ethynylphenyl)-2,6,7-trioxabi cyclo[2.2.2]octane: synthesis of a remarkably potent GABAA receptor antagonist

J Med Chem. 1988 Jun;31(6):1064-6. doi: 10.1021/jm00401a002.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bridged Bicyclo Compounds / metabolism
  • Bridged Bicyclo Compounds, Heterocyclic*
  • Chlorides / metabolism
  • Convulsants / chemical synthesis*
  • Convulsants / pharmacology
  • GABA Antagonists*
  • Mice
  • Rats
  • Receptors, GABA-A / drug effects*

Substances

  • Bridged Bicyclo Compounds
  • Bridged Bicyclo Compounds, Heterocyclic
  • Chlorides
  • Convulsants
  • GABA Antagonists
  • Receptors, GABA-A
  • tert-butylbicyclophosphorothionate