Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development

FEBS Lett. 2000 Mar 3;469(1):19-23. doi: 10.1016/s0014-5793(00)01247-3.

Abstract

A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues and various developmental stages of the mouse brain. MINK encodes a 1300 amino acid polypeptide, consisting of an N-terminal kinase domain, a proline-rich intermediate region, and a C-terminal GCK homology region. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / enzymology*
  • Brain / growth & development
  • Cell Line
  • Cloning, Molecular
  • Enzyme Activation
  • Gene Expression Regulation, Developmental
  • Germinal Center Kinases
  • Mice
  • Mitogen-Activated Protein Kinases / genetics
  • Mitogen-Activated Protein Kinases / metabolism
  • Molecular Sequence Data
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics*
  • Phylogeny
  • Protein Serine-Threonine Kinases / chemistry
  • Protein Serine-Threonine Kinases / genetics*
  • RNA, Messenger / metabolism
  • Signal Transduction
  • Transfection
  • Up-Regulation

Substances

  • Germinal Center Kinases
  • Nerve Tissue Proteins
  • RNA, Messenger
  • Protein Serine-Threonine Kinases
  • Mitogen-Activated Protein Kinases

Associated data

  • GENBANK/AB035697
  • GENBANK/AB035698