Abstract
A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues and various developmental stages of the mouse brain. MINK encodes a 1300 amino acid polypeptide, consisting of an N-terminal kinase domain, a proline-rich intermediate region, and a C-terminal GCK homology region. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways.
MeSH terms
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Amino Acid Sequence
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Animals
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Brain / enzymology*
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Brain / growth & development
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Cell Line
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Cloning, Molecular
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Enzyme Activation
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Gene Expression Regulation, Developmental
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Germinal Center Kinases
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Mice
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Mitogen-Activated Protein Kinases / genetics
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Mitogen-Activated Protein Kinases / metabolism
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Molecular Sequence Data
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / genetics*
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Phylogeny
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Protein Serine-Threonine Kinases / chemistry
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Protein Serine-Threonine Kinases / genetics*
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RNA, Messenger / metabolism
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Signal Transduction
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Transfection
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Up-Regulation
Substances
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Germinal Center Kinases
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Nerve Tissue Proteins
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RNA, Messenger
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Protein Serine-Threonine Kinases
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Mitogen-Activated Protein Kinases
Associated data
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GENBANK/AB035697
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GENBANK/AB035698