Abstract
Mouse goosecoid is a homeobox gene expressed briefly during early gastrulation. Its mRNA accumulates as a patch on the side of the epiblast at the site where the primitive streak is first formed. goosecoid-expressing cells are then found at the anterior end of the developing primitive streak, and finally in the anteriormost mesoderm at the tip of the early mouse gastrula, a region that gives rise to the head process. Treatment of early mouse embryos with activin results in goosecoid mRNA accumulation in the entire epiblast, suggesting that a localized signal induces goosecoid expression during development. Transplantation experiments indicate that the tip of the murine early gastrula is the equivalent of the organizer of the amphibian gastrula.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Activins
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Amino Acid Sequence
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Animals
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Base Sequence
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DNA-Binding Proteins / analysis*
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Embryonic Induction / drug effects
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Embryonic Induction / genetics*
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Gastrula / drug effects
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Gene Expression
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Genes, Homeobox*
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Goosecoid Protein
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Homeodomain Proteins*
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Inhibins / pharmacology
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Mesoderm / drug effects
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Mice
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Mice, Inbred Strains
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Molecular Sequence Data
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RNA, Messenger / analysis
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Repressor Proteins*
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Transcription Factors*
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Xenopus / embryology
Substances
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DNA-Binding Proteins
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Goosecoid Protein
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Gsc protein, mouse
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Homeodomain Proteins
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RNA, Messenger
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Repressor Proteins
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Transcription Factors
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Activins
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Inhibins
Associated data
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GENBANK/M63872
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GENBANK/M84163
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GENBANK/M84182
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GENBANK/M85271
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GENBANK/S72766
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GENBANK/S72767
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GENBANK/S72768
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GENBANK/S72769
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GENBANK/S72771
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GENBANK/X63098