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Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.
Litschko C, Brühmann S, Csiszár A, Stephan T, Dimchev V, Damiano-Guercio J, Junemann A, Körber S, Winterhoff M, Nordholz B, Ramalingam N, Peckham M, Rottner K, Merkel R, Faix J. Litschko C, et al. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3594-3603. doi: 10.1073/pnas.1821638116. Epub 2019 Feb 11. Proc Natl Acad Sci U S A. 2019. PMID: 30808751 Free PMC article.
mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.
Sakamoto S, Thumkeo D, Ohta H, Zhang Z, Huang S, Kanchanawong P, Fuu T, Watanabe S, Shimada K, Fujihara Y, Yoshida S, Ikawa M, Watanabe N, Saitou M, Narumiya S. Sakamoto S, et al. PLoS Biol. 2018 Sep 26;16(9):e2004874. doi: 10.1371/journal.pbio.2004874. eCollection 2018 Sep. PLoS Biol. 2018. PMID: 30256801 Free PMC article.