PubMed (GeneRIF) for id: 22427

Year	Number of Results
2003	1
2005	1
2006	1
2007	1
2008	1
2009	1
2010	3
2011	2
2012	2
2014	1
2015	3
2018	1
2021	1
2024	0

1

WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.

Datta A, Biswas K, Sommers JA, Thompson H, Awate S, Nicolae CM, Thakar T, Moldovan GL, Shoemaker RH, Sharan SK, Brosh RM Jr. Datta A, et al. Nat Commun. 2021 Nov 12;12(1):6561. doi: 10.1038/s41467-021-26811-w. Nat Commun. 2021. PMID: 34772932 Free PMC article.

2

Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein.

Aumailley L, Roux-Dalvai F, Kelly I, Droit A, Lebel M. Aumailley L, et al. PLoS One. 2018 Mar 1;13(3):e0193170. doi: 10.1371/journal.pone.0193170. eCollection 2018. PLoS One. 2018. PMID: 29494634 Free PMC article.

3

Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase.

Aumailley L, Dubois MJ, Garand C, Marette A, Lebel M. Aumailley L, et al. Exp Gerontol. 2015 Dec;72:192-203. doi: 10.1016/j.exger.2015.10.012. Epub 2015 Oct 29. Exp Gerontol. 2015. PMID: 26521679

4

Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.

Aumailley L, Garand C, Dubois MJ, Johnson FB, Marette A, Lebel M. Aumailley L, et al. PLoS One. 2015 Oct 8;10(10):e0140292. doi: 10.1371/journal.pone.0140292. eCollection 2015. PLoS One. 2015. PMID: 26447695 Free PMC article.

5

The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.

Chung L, Onyango D, Guo Z, Jia P, Dai H, Liu S, Zhou M, Lin W, Pang I, Li H, Yuan YC, Huang Q, Zheng L, Lopes J, Nicolas A, Chai W, Raz D, Reckamp KL, Shen B. Chung L, et al. Oncogene. 2015 Feb 12;34(7):902-11. doi: 10.1038/onc.2014.19. Epub 2014 Mar 10. Oncogene. 2015. PMID: 24608430 Free PMC article.

6

Loss of p16(Ink4a) function rescues cellular senescence induced by telomere dysfunction.

Zhang X, Wu X, Tang W, Luo Y. Zhang X, et al. Int J Mol Sci. 2012;13(5):5866-5877. doi: 10.3390/ijms13055866. Epub 2012 May 16. Int J Mol Sci. 2012. PMID: 22754337 Free PMC article.

7

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.

Moser R, Toyoshima M, Robinson K, Gurley KE, Howie HL, Davison J, Morgan M, Kemp CJ, Grandori C. Moser R, et al. Mol Cancer Res. 2012 Apr;10(4):535-45. doi: 10.1158/1541-7786.MCR-11-0508. Epub 2012 Feb 1. Mol Cancer Res. 2012. PMID: 22301954 Free PMC article.

8

The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold attachment factor B1 deficient mice.

Lachapelle S, Oesterreich S, Lebel M. Lachapelle S, et al. Aging (Albany NY). 2011 Mar;3(3):277-90. doi: 10.18632/aging.100300. Aging (Albany NY). 2011. PMID: 21464516 Free PMC article.

9

BCR/ABL stimulates WRN to promote survival and genomic instability.

Slupianek A, Poplawski T, Jozwiakowski SK, Cramer K, Pytel D, Stoczynska E, Nowicki MO, Blasiak J, Skorski T. Slupianek A, et al. Cancer Res. 2011 Feb 1;71(3):842-51. doi: 10.1158/0008-5472.CAN-10-1066. Epub 2010 Dec 1. Cancer Res. 2011. PMID: 21123451 Free PMC article.

10

Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes.

Rahn JJ, Lowery MP, Della-Coletta L, Adair GM, Nairn RS. Rahn JJ, et al. Mech Ageing Dev. 2010 Sep;131(9):562-73. doi: 10.1016/j.mad.2010.08.001. Epub 2010 Aug 12. Mech Ageing Dev. 2010. PMID: 20708636 Free PMC article.

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