PubMed for id: 26404

Year	Number of Results
1994	1
1996	4
1997	2
1999	1
2000	4
2001	1
2002	3
2003	2
2004	5
2005	3
2006	2
2007	3
2008	7
2009	8
2010	1
2011	4
2012	3
2013	5
2014	4
2015	4
2016	5
2017	4
2018	1
2019	2
2020	1
2021	2
2022	2
2024	0

1

A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.

Katz JS, Rothstein JD, Cudkowicz ME, Genge A, Oskarsson B, Hains AB, Chen C, Galanter J, Burgess BL, Cho W, Kerchner GA, Yeh FL, Ghosh AS, Cheeti S, Brooks L, Honigberg L, Couch JA, Rothenberg ME, Brunstein F, Sharma KR, van den Berg L, Berry JD, Glass JD. Katz JS, et al. Ann Clin Transl Neurol. 2022 Jan;9(1):50-66. doi: 10.1002/acn3.51491. Epub 2022 Jan 10. Ann Clin Transl Neurol. 2022. PMID: 35014217 Free PMC article. Clinical Trial.

2

High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity.

Verschuuren M, Verstraelen P, García-Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, Larsen PH, Nuydens R, De Vos WH. Verschuuren M, et al. Acta Neuropathol Commun. 2019 Jun 4;7(1):93. doi: 10.1186/s40478-019-0741-3. Acta Neuropathol Commun. 2019. PMID: 31164177 Free PMC article.

3

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.

Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, Maloney J, Gandham VD, Pozniak CD, Wang B, Lee S, Siu M, Patel S, Modrusan Z, Liu X, Rudhard Y, Baca M, Gustafson A, Kaminker J, Carano RAD, Huang EJ, Foreman O, Weimer R, Scearce-Levie K, Lewcock JW. Le Pichon CE, et al. Sci Transl Med. 2017 Aug 16;9(403):eaag0394. doi: 10.1126/scitranslmed.aag0394. Sci Transl Med. 2017. PMID: 28814543

4

Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells.

Blondeau A, Lucier JF, Matteau D, Dumont L, Rodrigue S, Jacques PÉ, Blouin R. Blondeau A, et al. Neural Dev. 2016 Jul 28;11(1):13. doi: 10.1186/s13064-016-0068-8. Neural Dev. 2016. PMID: 27468987 Free PMC article.

5

Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.

Wallbach M, Duque Escobar J, Babaeikelishomi R, Stahnke MJ, Blume R, Schröder S, Kruegel J, Maedler K, Kluth O, Kehlenbach RH, Miosge N, Oetjen E. Wallbach M, et al. Cell Signal. 2016 Apr;28(4):272-83. doi: 10.1016/j.cellsig.2016.01.002. Epub 2016 Jan 9. Cell Signal. 2016. PMID: 26776303

6

Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.

Valakh V, Frey E, Babetto E, Walker LJ, DiAntonio A. Valakh V, et al. Neurobiol Dis. 2015 May;77:13-25. doi: 10.1016/j.nbd.2015.02.014. Epub 2015 Feb 26. Neurobiol Dis. 2015. PMID: 25726747 Free PMC article.

7

An in vitro assay to study induction of the regenerative state in sensory neurons.

Frey E, Valakh V, Karney-Grobe S, Shi Y, Milbrandt J, DiAntonio A. Frey E, et al. Exp Neurol. 2015 Jan;263:350-63. doi: 10.1016/j.expneurol.2014.10.012. Epub 2014 Nov 4. Exp Neurol. 2015. PMID: 25447942 Free PMC article.

8

The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation.

Couture JP, Daviau A, Fradette J, Blouin R. Couture JP, et al. PLoS One. 2009;4(3):e4743. doi: 10.1371/journal.pone.0004743. Epub 2009 Mar 9. PLoS One. 2009. PMID: 19270737 Free PMC article.

9

Activation of the dual-leucine-zipper-bearing kinase and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A.

Plaumann S, Blume R, Börchers S, Steinfelder HJ, Knepel W, Oetjen E. Plaumann S, et al. Mol Pharmacol. 2008 Mar;73(3):652-9. doi: 10.1124/mol.107.040782. Epub 2007 Nov 27. Mol Pharmacol. 2008. PMID: 18042735

10

Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts.

Tanimizu N, Saito H, Mostov K, Miyajima A. Tanimizu N, et al. J Cell Sci. 2004 Dec 15;117(Pt 26):6425-34. doi: 10.1242/jcs.01572. Epub 2004 Nov 30. J Cell Sci. 2004. PMID: 15572411

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