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38591790,38422113,38290242,38277467,38266517,38261982,38252412,38183652,38178578,38002982,37914747,37855870,37813308,37793650,37762112,37741764,37739033,37608120,37605276,37592884,37569549,37540751,37532939,37527763,37496071,37450246,37431963,37386798,37259156,37218694,37147573,37080969,37046309,37046025,37039659,36930291,36898615,36823441,36812677,36732882,36709343,36634675,36463537,36442745,36430231,36293362,36264254,36053560,36038081,36007056,35954242,35932023,35879741,35871544,35835219,35807552,35793404,35771920,35758309,35751132,35708789,35696592,35644946,35641224,35604654,35551470,35511239,35490297,35438230,35320398,35294549,35239007,35229461,35227277,35168140,35112738,35076694,35053327,35044790,34966974,34944548,34930382,34913181,34880495,34558120,34548609,34469713,34404845,34390468,34380047,34378050,34371283,34363810,34339840,34333853,34271284,34199367,34131277,34112944,34109652,34048071,34002018,33969528,33909608,33888768,33832769,33803845,33744316,33712624,33692125,33624322,33579840,33577819,33479441,33461623,33452055,33433877,33421065,33361387,33337372,33335017,33301444,33300249,33155043,33151007,33097688,33068411,33064315,33026249,33003404,32872449,32759188,32731393,32657153,32529876,32422502,32408057,32343854,32337711,32253937,32157757,32132204,32007267,31951008,31929165,31914861,31898895,31852254,31780563,31759630,31714900,31705957,31661037,31655156,31653829,31562527,31515300,31430111,31357627,31287959,31235914,31186504,31067307,31042469,31039256,31036551,31035038,30922392,30905713,30824544,30814253,30785719,30742796,30742062,30630951,30604226,30578840,30540446,30520513,30520303,30511086,30453234,30413172,30310141,30309612,30120199,30030753,30030424,30010126,29987190,29912613,29804146,29801890,29787578,29786080,29779213,29728564,29665116,29653597,29630989,29621978,29562314,29513014,29511089,29438978,29097807,28988034,28952053,28919059,28859337,28848086,28833982,28833898,28794432,28793209,28789478,28733604,28599005,28566288,28549443,28521037,28482850,28467211,28357566,28334913,28332094,28330421,28301478,28257838,28172957,28167528,28122516,28112502,27920024,27786596,27757524,27545621,27495267,27445339,27445147,27257061,27155453,27040765,27030292,26980269,26971127,26915990,26810591,26757674,26756435,26723245,26639158,26598621,26581115,26507309,26444430,26437864,26410029,26327808,26311746,26261209,26250685,26224156,26197969,26172304,26091809,26002100,25998392,25976304,25933387,25921485,25853458,25788357,25652699,25637145,25630387,25556531,25519967,25503365,25408367,25359468,25215604,25202836,25171271,25170584,25127017,25122661,25039310,24860144,24785678,24760339,24750229,24721672,24698978,24659241,24651281,24591609,24507183,24497641,24477737,24464995,24462217,24440855,24440310,24424030,24407427,24378564,24300238,24256250,24252504,24240737,24240615,24220679,24113842,24080705,24066851,23874513,23840565,23742895,23740936,23737961,23721326,23704877,23686809,23604587,23558684,23546887,23475610,23372158,23327806,23317354,23300771,23235148,23231971,23138004,23124365,23097605,23092511,23062702,22944662,22873561,22835933,22804696,22797246,22752089,22751173,22691390,22575358,22539580,22506890,22456481,22424122,22406069,22405725,22398199,22257502,22252998,22156203,22127299,22029574,21956716,21946215,21899152,21830155,21706176,21678031,21647631,21454607,21454603,21450909,21421050,21418058,21358640,21355045,21220647,21209826,21172844,21172843,21131904,21126161,21120508,21086759,20959352,20951205,20948999,20937952,20708823,20702714,20697052,20675015,20645878,20621187,20600671,20558945,20555136,20554523,20447446,20423455,20301761,20225928,20175762,20154440,20133711,20082726,20071528,20055380,20047951,20043239,20031275,20008652,19944744,19938687,19887443,19864664,19864663,19833869,19816201,19815002,19808791,19786775,19765185,19760257,19714537,19695877,19685386,19664364,19618195,19609911,19560462,19533646,19526244,19515851,19465477,19455346,19422539,19411082,19350673,19338576,19330339,19306141,19285963,19283396,19236453,19235466,19225410,19224587,19204154,19164285,19139911,19139310,19125255,19111550,19066918,19039597,18989684,18974920,18931000,18929508,18923836,18802454,18779421,18755042,18657254,18656473,18634762,18592312,18549326,18546284,18545701,18520774,18506455,18505686,18438952,18396105,18379440,18304732,18206910,18088371,18087705,18068872,17569066,17492294,17360763,16157593,11470789,38568058,38404440,38347588,38311174,38232138,38139294,38115557,37951930,37669322,37647804,37218402,37075107,37037195,37012364,36963381,36675095,36641675,36456471,36369320,36077049,36075972,35787294,35568729,35504883,35344984,35314728,35264561,35197628,35197626,34824257,34769284,34445680,34290285,34107054,34082062,34031922,33971027,33924373,33855783,33852834,33771571,33622418,33588953,33454579,33441818,33433879,33398173,33391478,33386850,33269497,33230138,33159016,33149110,33144500,33065281,32907630,32882370,32800996,32790644,32758633,32558493,32393629,32330447,32301481,32142134,31953403,31863590,31801077,31728929,31703746,31693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1,039 results

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Anterior insula is more vulnerable than posterior insula to TDP-43 pathology in common dementias and ALS.

Lochner RH, Arumanayagam AS, Powell SZ, Masdeu JC, Pascual B, Cykowski MD. Lochner RH, et al. J Neuropathol Exp Neurol. 2024 Apr 19;83(5):307-317. doi: 10.1093/jnen/nlae027. J Neuropathol Exp Neurol. 2024. PMID: 38591790 Free PMC article.

RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention.

Dos Passos PM, Hemamali EH, Mamede LD, Hayes LR, Ayala YM. Dos Passos PM, et al. PLoS Biol. 2024 Feb 29;22(2):e3002527. doi: 10.1371/journal.pbio.3002527. eCollection 2024 Feb. PLoS Biol. 2024. PMID: 38422113 Free PMC article.

Genetically encoded lysine photocage for spatiotemporal control of TDP-43 nuclear import.

Shadish JA, Lee JC. Shadish JA, et al. Biophys Chem. 2024 Apr;307:107191. doi: 10.1016/j.bpc.2024.107191. Epub 2024 Jan 23. Biophys Chem. 2024. PMID: 38290242 Free article.

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.

Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang YJ, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Kargbo-Hill SE, Hawrot J, Ramos DM, Yuan H, Roberts J, Sacramento EK, Shah SI, Nalls MA, Colón-Mercado JM, Reyes JF, Ryan VH, Nelson MP, Cook CN, Li Z, Screven L, Kwan JY, Mehta PR, Zanovello M, Hallegger M, Shantaraman A, Ping L, Koike Y, Oskarsson B, Staff NP, Duong DM, Ahmed A, Secrier M, Ule J, Jacobson S, Reich DS, Rohrer JD, Malaspina A, Dickson DW, Glass JD, Ori A, Seyfried NT, Maragkakis M, Petrucelli L, Fratta P, Ward ME. Seddighi S, et al. Sci Transl Med. 2024 Feb 14;16(734):eadg7162. doi: 10.1126/scitranslmed.adg7162. Epub 2024 Feb 14. Sci Transl Med. 2024. PMID: 38277467

The influence of limbic-predominant age-related TDP-43 encephalopathy on argyrophilic grain disease: A voxel-based morphometry analysis of pathologically confirmed cases.

Inui S, Kaneda D, Sakurai K, Morimoto S, Uchida Y, Abe O, Hashizume Y. Inui S, et al. J Neurol Sci. 2024 Feb 15;457:122894. doi: 10.1016/j.jns.2024.122894. Epub 2024 Jan 19. J Neurol Sci. 2024. PMID: 38266517

Cognitive and Behavioral Features of Patients With Amyotrophic Lateral Sclerosis Who Are Carriers of the TARDBP Pathogenic Variant.

Moglia C, Calvo A, Canosa A, Manera U, Vasta R, Di Pede F, Daviddi M, Matteoni E, Brunetti M, Sbaiz L, Cabras S, Gallone S, Grassano M, Peotta L, Palumbo F, Mora G, Iazzolino B, Chio A. Moglia C, et al. Neurology. 2024 Feb 27;102(4):e208082. doi: 10.1212/WNL.0000000000208082. Epub 2024 Jan 23. Neurology. 2024. PMID: 38261982 Free PMC article.

IκB kinase thwarts aggregation: Phosphorylating TDP-43 for degradation.

Yang C, Liu Y, Hu F. Yang C, et al. J Cell Biol. 2024 Feb 5;223(2):e202311176. doi: 10.1083/jcb.202311176. Epub 2024 Jan 22. J Cell Biol. 2024. PMID: 38252412 Free article.

TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis.

Guise AJ, Misal SA, Carson R, Chu JH, Boekweg H, Van Der Watt D, Welsh NC, Truong T, Liang Y, Xu S, Benedetto G, Gagnon J, Payne SH, Plowey ED, Kelly RT. Guise AJ, et al. Cell Rep. 2024 Jan 23;43(1):113636. doi: 10.1016/j.celrep.2023.113636. Epub 2024 Jan 5. Cell Rep. 2024. PMID: 38183652 Free PMC article.

Phosphomimetic substitutions in TDP-43's transiently α-helical region suppress phase separation.

Haider R, Penumutchu S, Boyko S, Surewicz WK. Haider R, et al. Biophys J. 2024 Feb 6;123(3):361-373. doi: 10.1016/j.bpj.2024.01.001. Epub 2024 Jan 4. Biophys J. 2024. PMID: 38178578 Free article.

Variability in Clinical Phenotype in TARDBP Mutations: Amyotrophic Lateral Sclerosis Case Description and Literature Review.

Lombardi M, Corrado L, Piola B, Comi C, Cantello R, D'Alfonso S, Mazzini L, De Marchi F. Lombardi M, et al. Genes (Basel). 2023 Nov 4;14(11):2039. doi: 10.3390/genes14112039. Genes (Basel). 2023. PMID: 38002982 Free PMC article.

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