PubMed for id: 21942

Year	Number of Results
1989	1
1992	1
1993	3
1994	2
1995	4
1996	1
1997	2
1998	2
1999	3
2000	7
2001	4
2002	14
2003	11
2004	11
2005	14
2006	9
2007	17
2008	13
2009	9
2010	12
2011	18
2012	14
2013	16
2014	8
2015	5
2016	7
2017	12
2018	4
2019	6
2020	12
2021	7
2022	4
2024	1

1

CD137 Regulates Bone Loss via the p53 Wnt/β-Catenin Signaling Pathways in Aged Mice.

Han J, Wang Y, Zhou H, Zhang Y, Wan D. Han J, et al. Front Endocrinol (Lausanne). 2022 Jun 30;13:922501. doi: 10.3389/fendo.2022.922501. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35846320 Free PMC article.

2

CD137 (4-1BB) costimulation of CD8⁺ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation.

Otano I, Azpilikueta A, Glez-Vaz J, Alvarez M, Medina-Echeverz J, Cortés-Domínguez I, Ortiz-de-Solorzano C, Ellmark P, Fritzell S, Hernandez-Hoyos G, Nelson MH, Ochoa MC, Bolaños E, Cuculescu D, Jaúregui P, Sanchez-Gregorio S, Etxeberria I, Rodriguez-Ruiz ME, Sanmamed MF, Teijeira Á, Berraondo P, Melero I. Otano I, et al. Nat Commun. 2021 Dec 15;12(1):7296. doi: 10.1038/s41467-021-27613-w. Nat Commun. 2021. PMID: 34911975 Free PMC article.

3

Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission.

Xu Y, Zhang Y, Xu Y, Zang G, Li B, Xia H, Yuan W. Xu Y, et al. Int J Biochem Cell Biol. 2021 Jul;136:106003. doi: 10.1016/j.biocel.2021.106003. Epub 2021 May 7. Int J Biochem Cell Biol. 2021. PMID: 33971320

4

Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice.

Wan D, Ai S, Ouyang H, Cheng L. Wan D, et al. Exp Mol Med. 2021 Apr;53(4):654-666. doi: 10.1038/s12276-021-00605-y. Epub 2021 Apr 15. Exp Mol Med. 2021. PMID: 33859350 Free PMC article.

5

Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation.

Kamata-Sakurai M, Narita Y, Hori Y, Nemoto T, Uchikawa R, Honda M, Hironiwa N, Taniguchi K, Shida-Kawazoe M, Metsugi S, Miyazaki T, Wada NA, Ohte Y, Shimizu S, Mikami H, Tachibana T, Ono N, Adachi K, Sakiyama T, Matsushita T, Kadono S, Komatsu SI, Sakamoto A, Horikawa S, Hirako A, Hamada K, Naoi S, Savory N, Satoh Y, Sato M, Noguchi Y, Shinozuka J, Kuroi H, Ito A, Wakabayashi T, Kamimura M, Isomura F, Tomii Y, Sawada N, Kato A, Ueda O, Nakanishi Y, Endo M, Jishage KI, Kawabe Y, Kitazawa T, Igawa T. Kamata-Sakurai M, et al. Cancer Discov. 2021 Jan;11(1):158-175. doi: 10.1158/2159-8290.CD-20-0328. Epub 2020 Aug 25. Cancer Discov. 2021. PMID: 32847940

6

4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis.

Miki H, Han KH, Scott D, Croft M, Kang YJ. Miki H, et al. J Immunol. 2020 Apr 1;204(7):1892-1903. doi: 10.4049/jimmunol.1900983. Epub 2020 Feb 10. J Immunol. 2020. PMID: 32041783 Free PMC article.

7

CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes/macrophages.

Jiang P, Gao W, Ma T, Wang R, Piao Y, Dong X, Wang P, Zhang X, Liu Y, Su W, Xiang R, Zhang J, Li N. Jiang P, et al. Theranostics. 2019 May 9;9(10):2950-2966. doi: 10.7150/thno.29617. eCollection 2019. Theranostics. 2019. PMID: 31244935 Free PMC article.

8

Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci.

Xu MM, Ménoret A, Nicholas SE, Günther S, Sundberg EJ, Zhou B, Rodriguez A, Murphy PA, Vella AT. Xu MM, et al. Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1480-H1494. doi: 10.1152/ajpheart.00088.2019. Epub 2019 Apr 12. Am J Physiol Heart Circ Physiol. 2019. PMID: 30978132 Free PMC article.

9

Increased Peripheral CD137 Expression in a Mouse Model of Permanent Focal Cerebral Ischemia.

Li XQ, Wang YY, Yang TT, Qian YN, Yin H, Zhong SS, A R, He Y, Xu BL, Liu GZ. Li XQ, et al. Cell Mol Neurobiol. 2019 Apr;39(3):451-460. doi: 10.1007/s10571-019-00661-z. Epub 2019 Feb 18. Cell Mol Neurobiol. 2019. PMID: 30778712

10

4-1BB Signaling Promotes Alveolar Macrophages-Mediated Pro-Fibrotic Responses and Crystalline Silica-Induced Pulmonary Fibrosis in Mice.

Lu Y, Li C, Du S, Chen X, Zeng X, Liu F, Chen Y, Chen J. Lu Y, et al. Front Immunol. 2018 Sep 10;9:1848. doi: 10.3389/fimmu.2018.01848. eCollection 2018. Front Immunol. 2018. PMID: 30250465 Free PMC article.

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