PubMed for id: 16591

Year	Number of Results
1996	1
1997	1
1998	2
1999	3
2000	13
2001	4
2002	11
2003	6
2004	8
2005	11
2006	10
2007	8
2008	13
2009	23
2010	21
2011	24
2012	24
2013	26
2014	25
2015	26
2016	32
2017	33
2018	28
2019	30
2020	35
2021	21
2022	16
2023	16
2024	1

1

Relationship of the bone phenotype of the Klotho mutant mouse model of accelerated aging to changes in skeletal architecture that occur with chronological aging.

Verlinden L, Li S, Veldurthy V, Carmeliet G, Christakos S. Verlinden L, et al. Front Endocrinol (Lausanne). 2024 Jan 30;15:1310466. doi: 10.3389/fendo.2024.1310466. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38352710 Free PMC article.

2

Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.

Jiang W, Gan C, Zhou X, Yang Q, Chen D, Xiao H, Dai L, Chen Y, Wang M, Yang H, Li Q. Jiang W, et al. Cardiovasc Diabetol. 2023 Oct 27;22(1):293. doi: 10.1186/s12933-023-02025-w. Cardiovasc Diabetol. 2023. PMID: 37891556 Free PMC article.

3

Klotho regulates the myogenic response of muscle to mechanical loading and exercise.

Ochi E, Barrington A, Wehling-Henricks M, Avila M, Kuro-O M, Tidball JG. Ochi E, et al. Exp Physiol. 2023 Dec;108(12):1531-1547. doi: 10.1113/EP091263. Epub 2023 Oct 20. Exp Physiol. 2023. PMID: 37864311 Free PMC article.

4

Klotho increases antioxidant defenses in astrocytes and ubiquitin-proteasome activity in neurons.

Orellana AM, Mazucanti CH, Dos Anjos LP, de Sá Lima L, Kawamoto EM, Scavone C. Orellana AM, et al. Sci Rep. 2023 Sep 12;13(1):15080. doi: 10.1038/s41598-023-41166-6. Sci Rep. 2023. PMID: 37699938 Free PMC article.

5

Extracellular Vesicles in Young Serum Contribute to the Restoration of Age-Related Brain Transcriptomes and Cognition in Old Mice.

Fitz NF, Sahu A, Lu Y, Ambrosio F, Lefterov I, Koldamova R. Fitz NF, et al. Int J Mol Sci. 2023 Aug 8;24(16):12550. doi: 10.3390/ijms241612550. Int J Mol Sci. 2023. PMID: 37628730 Free PMC article.

6

Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice.

Park C, Hahn O, Gupta S, Moreno AJ, Marino F, Kedir B, Wang D, Villeda SA, Wyss-Coray T, Dubal DB. Park C, et al. Nat Aging. 2023 Sep;3(9):1067-1078. doi: 10.1038/s43587-023-00468-0. Epub 2023 Aug 16. Nat Aging. 2023. PMID: 37587231 Free PMC article.

7

Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium.

Jang HY, Kim SJ, Park KS, Kim JH. Jang HY, et al. Cell Death Dis. 2023 May 20;14(5):334. doi: 10.1038/s41419-023-05851-8. Cell Death Dis. 2023. PMID: 37210384 Free PMC article.

8

Klotho alleviates contrast-induced acute kidney injury by suppressing oxidative stress, inflammation, and NF-KappaB/NLRP3-mediated pyroptosis.

Fu Y, Cao J, Wei X, Ge Y, Su Z, Yu D. Fu Y, et al. Int Immunopharmacol. 2023 May;118:110105. doi: 10.1016/j.intimp.2023.110105. Epub 2023 Apr 3. Int Immunopharmacol. 2023. PMID: 37018977

9

mTORC1-Induced Bone Marrow-Derived Mesenchymal Stem Cell Exhaustion Contributes to the Bone Abnormalities in Klotho-Deficient Mice of Premature Aging.

Feng R, Wu S, Li R, Huang K, Zeng T, Zhou Z, Zhong X, Songyang Z, Liu F. Feng R, et al. Stem Cells Dev. 2023 Jun;32(11-12):331-345. doi: 10.1089/scd.2022.0243. Epub 2023 Apr 17. Stem Cells Dev. 2023. PMID: 36924305

10

Soluble Klotho protects against glomerular injury through regulation of ER stress response.

Charrin E, Dabaghie D, Sen I, Unnersjö-Jess D, Möller-Hackbarth K, Burmakin M, Mencke R, Zambrano S, Patrakka J, Olauson H. Charrin E, et al. Commun Biol. 2023 Feb 22;6(1):208. doi: 10.1038/s42003-023-04563-1. Commun Biol. 2023. PMID: 36813870 Free PMC article.

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