SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.
PLoS Genet. 2015.
PMID: 26134849
Free PMC article.
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SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.
Hu S, Li J, Xu F, Mei S, Le Duff Y, Yin L, Pang X, Cen S, Jin Q, Liang C, Guo F.
Hu S, et al.
PLoS Genet. 2015 Jul 2;11(7):e1005367. doi: 10.1371/journal.pgen.1005367. eCollection 2015 Jul.
PLoS Genet. 2015.
PMID: 26134849
Free PMC article.
This function of SAMHD1 enhances sequestration of LINE-1 RNP in stress granules and consequent blockade to LINE-1 retrotransposition. In support of this new mechanism of action, depletion of stress granule mark …
This function of SAMHD1 enhances sequestration of LINE-1 RNP in stress granules and consequent blockade t …
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Stress out the LINEs.
Hu S, Liang C, Guo F.
Hu S, et al.
Mob Genet Elements. 2015 Dec 29;6(1):e1133267. doi: 10.1080/2159256X.2015.1133267. eCollection 2016 Jan-Feb.
Mob Genet Elements. 2015.
PMID: 27066303
Free PMC article.
This mechanism functions by sequestering the LINE-1 RNA-protein complex within the cytoplasmic stress granules and thus inhibiting the nuclear import of LINE-1 RNA and its subsequent reverse transcription and integration into cellu …
This mechanism functions by sequestering the LINE-1 RNA-protein complex within the cytoplasmic stress granules a …
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