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Intestinal invalidation of the glucose transporter GLUT2 delays tissue distribution of glucose and reveals an unexpected role in gut homeostasis.
Schmitt CC, Aranias T, Viel T, Chateau D, Le Gall M, Waligora-Dupriet AJ, Melchior C, Rouxel O, Kapel N, Gourcerol G, Tavitian B, Lehuen A, Brot-Laroche E, Leturque A, Serradas P, Grosfeld A. Schmitt CC, et al. Mol Metab. 2016 Nov 4;6(1):61-72. doi: 10.1016/j.molmet.2016.10.008. eCollection 2017 Jan. Mol Metab. 2016. PMID: 28123938 Free PMC article.
Hepatic glucose sensing is required to preserve β cell glucose competence.
Seyer P, Vallois D, Poitry-Yamate C, Schütz F, Metref S, Tarussio D, Maechler P, Staels B, Lanz B, Grueter R, Decaris J, Turner S, da Costa A, Preitner F, Minehira K, Foretz M, Thorens B. Seyer P, et al. J Clin Invest. 2013 Apr;123(4):1662-76. doi: 10.1172/JCI65538. Epub 2013 Mar 15. J Clin Invest. 2013. PMID: 23549084 Free PMC article.