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Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage.
EMBO J. 1997 Apr 1;16(7):1508-18. doi: 10.1093/emboj/16.7.1508.
EMBO J. 1997.
PMID: 9130696
Free PMC article.
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.
Anderson ED, Molloy SS, Jean F, Fei H, Shimamura S, Thomas G.
Anderson ED, et al.
J Biol Chem. 2002 Apr 12;277(15):12879-90. doi: 10.1074/jbc.M108740200. Epub 2002 Jan 17.
J Biol Chem. 2002.
PMID: 11799113
Free PMC article.
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