Isolation and sequence of a full length cDNA encoding a novel rat inositol 1,4,5-trisphosphate 3-kinase

S Thomas; B Brake; J P Luzio; K Stanley; G Banting

doi:10.1016/0167-4889(94)90139-2

Isolation and sequence of a full length cDNA encoding a novel rat inositol 1,4,5-trisphosphate 3-kinase

Biochim Biophys Acta. 1994 Jan 13;1220(2):219-22. doi: 10.1016/0167-4889(94)90139-2.

Authors

S Thomas¹, B Brake, J P Luzio, K Stanley, G Banting

Affiliation

¹ Department of Biochemistry, University of Bristol, UK.

PMID: 8312366
DOI: 10.1016/0167-4889(94)90139-2

Abstract

Immunoscreening a rat liver cDNA expression library has led to the isolation of a full-length cDNA clone encoding a novel isoform of rat inositol 1,4,5-trisphosphate 3-kinase (IP3 3-kinase). Sequence comparison shows it (i) to be 93% identical to human hippocampus IP3 3-kinase B over 468 residues at the protein level, and (ii) to encode a protein 204 amino acids larger than the published sequence of its human homologue.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
DNA, Complementary / chemistry
DNA, Complementary / isolation & purification*
Molecular Sequence Data
Phosphotransferases (Alcohol Group Acceptor) / genetics*
Rats
Sequence Alignment
Sequence Homology, Nucleic Acid

Substances

DNA, Complementary
Phosphotransferases (Alcohol Group Acceptor)
Inositol 1,4,5-trisphosphate 3-kinase

Associated data

GENBANK/X74227