A 62-year-old Japanese male with a 40-year history of heavy smoking presented with a laryngeal verrucous carcinoma on his left vocal cord (T1a N0 M0). The lesion was treated with tegafur. Three weeks after the start of treatment the lesion had almost entirely disappeared, with only a small scar remaining. The vocal cords were stripped to remove the scar. Thirty months after tegafur treatment the patient shows no indications of recurrence or metastasis.