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Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.
EMBO J. 1995 Aug 1;14(15):3599-608. doi: 10.1002/j.1460-2075.1995.tb00029.x.
EMBO J. 1995.
PMID: 7641679
Free PMC article.
Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10.
Ketscher A, Ketterer S, Dollwet-Mack S, Reif U, Reinheckel T.
Ketscher A, et al.
Biochimie. 2016 Mar;122:219-26. doi: 10.1016/j.biochi.2015.07.020. Epub 2015 Jul 29.
Biochimie. 2016.
PMID: 26232697
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Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury.
Suzuki C, Tanida I, Ohmuraya M, Oliva Trejo JA, Kakuta S, Sunabori T, Uchiyama Y.
Suzuki C, et al.
Int J Mol Sci. 2019 Apr 5;20(7):1711. doi: 10.3390/ijms20071711.
Int J Mol Sci. 2019.
PMID: 30959855
Free PMC article.
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Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity.
Mehanna S, Suzuki C, Shibata M, Sunabori T, Imanaka T, Araki K, Yamamura K, Uchiyama Y, Ohmuraya M.
Mehanna S, et al.
Biochem Biophys Res Commun. 2016 Jan 15;469(3):405-11. doi: 10.1016/j.bbrc.2015.12.002. Epub 2015 Dec 9.
Biochem Biophys Res Commun. 2016.
PMID: 26682926
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Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.
Koike M, Shibata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, Tanaka K, Uchiyama Y.
Koike M, et al.
Am J Pathol. 2017 Jul;187(7):1586-1600. doi: 10.1016/j.ajpath.2017.02.020. Epub 2017 May 11.
Am J Pathol. 2017.
PMID: 28502476
Free article.
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