Abstract
A hippocampal 38 kd autoantigen recognized by an autoantibody from the serum of a patient with paraneoplastic limbic encephalitis (PLE) and small cell lung carcinoma (SCLC) was isolated by screening a human hippocampal cDNA library. The 1,991-nucleotide ple21 clone was obtained and the deduced 350-residue protein encoded by the ple21 cDNA clone was found to be highly homologous to the neuron-specific RNA recognition motifs (RRMs)-containing proteins. The homologies were confined to the RRMs and the RRM connecting region. The presence of RRM in the antigenic protein may be important in the pathogenesis of SCLC-associated paraneoplastic neurologic syndrome.
Publication types
-
Case Reports
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Autoantigens / biosynthesis*
-
Base Sequence
-
Carcinoma, Small Cell / metabolism*
-
Cerebellum / metabolism
-
Cloning, Molecular
-
DNA, Complementary / metabolism
-
ELAV Proteins
-
ELAV-Like Protein 3
-
Frontal Lobe / metabolism
-
Ganglia, Spinal / metabolism
-
Gene Library
-
Hippocampus / metabolism*
-
Humans
-
Lung Neoplasms / metabolism*
-
Male
-
Middle Aged
-
Molecular Sequence Data
-
Nerve Tissue Proteins / biosynthesis*
-
Paraneoplastic Syndromes / metabolism*
-
Poly A / isolation & purification
-
Poly A / metabolism
-
RNA / isolation & purification
-
RNA / metabolism
-
RNA, Messenger
-
RNA-Binding Proteins*
-
Recombinant Proteins / biosynthesis
-
Sequence Homology, Amino Acid
Substances
-
Autoantigens
-
DNA, Complementary
-
ELAV Proteins
-
ELAV-Like Protein 3
-
ELAVL3 protein, human
-
Nerve Tissue Proteins
-
RNA, Messenger
-
RNA-Binding Proteins
-
Recombinant Proteins
-
Poly A
-
RNA