Surface LDLR is a major receptor for lipoprotein(a) clearance in male mice lacking PCSK9

Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Apr;1868(4):159288. doi: 10.1016/j.bbalip.2023.159288. Epub 2023 Jan 25.

Authors

Anna Roubtsova¹, Corey A Scipione², Damien Garçon¹, Michael B Boffa², Nabil G Seidah¹, Marlys L Koschinsky², Annik Prat³

Affiliations

¹ Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Montreal, QC, Canada.
² Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
³ Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Montreal, QC, Canada. Electronic address: Annik.Prat@ircm.qc.ca.

PMID: 36708961
DOI: 10.1016/j.bbalip.2023.159288

No abstract available

Keywords: Apo(a); Cholesterol; Lipoprotein clearance; Sex.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Lipoprotein(a)* / genetics
Liver
Male
Mice
Proprotein Convertase 9* / genetics
Receptors, LDL / genetics

Substances

PCSK9 protein, human
Proprotein Convertase 9
Lipoprotein(a)
Receptors, LDL
Pcsk9 protein, mouse

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