DNA-PK hyperactivation occurs in deletion 11q chronic lymphocytic leukemia and is both a biomarker and therapeutic target for drug-resistant disease

Sara E F Kost; Ali Saleh; Shek H Yuan; Bozena Kuzio; Spencer B Gibson; Lin Yang; Versha Banerji; James B Johnston; Sachin Katyal

doi:10.1038/s41408-022-00781-8

DNA-PK hyperactivation occurs in deletion 11q chronic lymphocytic leukemia and is both a biomarker and therapeutic target for drug-resistant disease

Blood Cancer J. 2023 Jan 27;13(1):20. doi: 10.1038/s41408-022-00781-8.

Authors

Sara E F Kost¹, Ali Saleh^{1

2}, Shek H Yuan^{1

2}, Bozena Kuzio^{1

2}, Spencer B Gibson^{1

3}, Lin Yang⁴, Versha Banerji^{1

4

5}, James B Johnston^#^{6

7}, Sachin Katyal^#^{8

9}

Affiliations

¹ CancerCare Manitoba Research Institute, CancerCare Manitoba, Winnipeg, MB, R3E 0V9, Canada.
² Department of Pharmacology and Therapeutics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R3E 3P4, Canada.
³ Department of Oncology, University of Alberta, Edmonton, AB, Canada.
⁴ Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R3E 3P4, Canada.
⁵ Department of Biochemistry and Medical Genetics Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R3E 3P4, Canada.
⁶ CancerCare Manitoba Research Institute, CancerCare Manitoba, Winnipeg, MB, R3E 0V9, Canada. jjohnsto@cancercare.mb.ca.
⁷ Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R3E 3P4, Canada. jjohnsto@cancercare.mb.ca.
⁸ CancerCare Manitoba Research Institute, CancerCare Manitoba, Winnipeg, MB, R3E 0V9, Canada. Sachin.Katyal@umanitoba.ca.
⁹ Department of Pharmacology and Therapeutics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R3E 3P4, Canada. Sachin.Katyal@umanitoba.ca.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Chromosome Deletion
Chromosomes, Human, Pair 11
DNA
DNA-Activated Protein Kinase / metabolism
DNA-Binding Proteins / metabolism
Drug Resistance, Neoplasm
Humans
Leukemia, Lymphocytic, Chronic, B-Cell* / drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Prognosis

Substances

Biomarkers
DNA
DNA-Activated Protein Kinase
DNA-Binding Proteins

Grants and funding

CIHR/Canada