Mitochondrial Stress Induces an HRI-eIF2α Pathway Protective for Cardiomyopathy

Circulation. 2022 Sep 27;146(13):1028-1031. doi: 10.1161/CIRCULATIONAHA.122.059594. Epub 2022 Sep 26.

Siting Zhu^#^{1

2}, Anh Nguyen^#¹, Jing Pang^#¹, Jun Zhao³, Ze'e Chen^{1

2}, Zhengyu Liang¹, Yusu Gu¹, Helen Huynh¹, Yutong Bao¹, Sharon Lee¹, Yuval Kluger³, Kunfu Ouyang², Sylvia M Evans^{1

4

5}, Xi Fang¹

¹ Department of Medicine (S.Z., A.N., J.P., Z.C., Z.L., Y.G., H.H., Y.B., S.L., S.M.E., X.F.), University of California San Diego, La Jolla.
² Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China (S.Z., Z.C., K.O.).
³ Department of Pathology, Yale School of Medicine, New Haven, CT (J.Z., Y.K.).
⁴ Department of Pharmacology (S.M.E.), University of California San Diego, La Jolla.
⁵ Skaggs School of Pharmacy and Pharmaceutical Sciences (S.M.E.), University of California San Diego, La Jolla.

^# Contributed equally.

No abstract available

Keywords: activating transcription factor 4; cardiomyopathy; heme-regulated eIF-2alpha kinase; mitochondria.

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