Oncogenic Signaling in Kidney Cancer Requires Renal Lineage Factor PAX8

Cancer Discov. 2022 Aug 5;12(8):1834. doi: 10.1158/2159-8290.CD-RW2022-113.

Abstract

Lineage factor PAX8 is essential for downstream oncogenic signaling of ccRCC-specific driver mutations.

Publication types

  • Comment

MeSH terms

  • Carcinoma, Renal Cell* / genetics
  • Carcinoma, Renal Cell* / metabolism
  • Humans
  • Kidney / metabolism
  • Kidney Neoplasms* / genetics
  • Kidney Neoplasms* / metabolism
  • Oncogenes
  • PAX8 Transcription Factor* / genetics
  • PAX8 Transcription Factor* / metabolism
  • Paired Box Transcription Factors / genetics
  • Signal Transduction

Substances

  • PAX8 Transcription Factor
  • PAX8 protein, human
  • Paired Box Transcription Factors