Lay A TRAP for myeloid cell response in diabetic kidney disease

Kidney Int. 2022 May;101(5):872-874. doi: 10.1016/j.kint.2022.02.001.

Abstract

The functions of the renin-angiotensin system are crucial in the progression of diabetic kidney disease. ATRAP is a type 1 angiotensin II receptor-associated protein that negatively regulates intracellular angiotensin II signaling. In this issue, Haruhara et al. revealed that ATRAP deficiency of diabetic mice decreases anti-inflammatory macrophage infiltration and exacerbates albuminuria. The adoptive transfer and tubule-specific depletion of ATRAP highlight the crosstalk between glomerular injury and tubulointerstitial angiotensin II signaling and innate immunity.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing* / genetics
  • Adaptor Proteins, Signal Transducing* / metabolism
  • Angiotensin II / metabolism
  • Animals
  • Diabetes Mellitus, Experimental* / metabolism
  • Diabetic Nephropathies* / etiology
  • Diabetic Nephropathies* / metabolism
  • Kidney / metabolism
  • Mice
  • Myeloid Cells / metabolism
  • Receptor, Angiotensin, Type 1 / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Agtrap protein, mouse
  • Receptor, Angiotensin, Type 1
  • Angiotensin II