Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c

Placenta. 2022 Mar 4:119:39-43. doi: 10.1016/j.placenta.2022.01.015. Epub 2022 Jan 31.

Abstract

Atypical protein kinase-c (aPKC) isoforms are important regulators of polarity and stem cell differentiation. There are three isoforms of aPKC: aPKC-ι, aPKC-ζ, and PKM-ζ. Recently, aPKC-ι was shown to regulate human trophoblast stem cell (TSC) differentiation. Compensation by remaining isoforms when a single aPKC isoform is lost can occur, but the expression pattern of aPKC-ζ in placenta is unknown. Here we show that aPKC-ι, aPKC-ζ and a new isoform, aPKC-ζ III, are expressed in trophoblasts. Therefore, studies examining the role of aPKC isoforms that control for potential compensation between aPKC isoforms are necessary to understand aPKC-mediated regulation of TSC differentiation.

Keywords: Atypical protein kinase-c; Placenta; Trophoblast; Trophoblast stem cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Isoenzymes / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Protein Kinase C / metabolism*
  • Trophoblasts / enzymology*

Substances

  • Isoenzymes
  • protein kinase C zeta
  • Protein Kinase C
  • protein kinase C lambda

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