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SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Nature. 2021 Nov;599(7883):136-140. doi: 10.1038/s41586-021-04025-w. Epub 2021 Oct 27.
Nature. 2021.
PMID: 34707288
Free PMC article.
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS.
Shi X, Reinstadler B, Shah H, To TL, Byrne K, Summer L, Calvo SE, Goldberger O, Doench JG, Mootha VK, Shen H.
Shi X, et al.
Nat Commun. 2022 May 5;13(1):2483. doi: 10.1038/s41467-022-30126-9.
Nat Commun. 2022.
PMID: 35513392
Free PMC article.
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Autoregulatory control of mitochondrial glutathione homeostasis.
Liu Y, Liu S, Tomar A, Yen FS, Unlu G, Ropek N, Weber RA, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano AE, Heissel S, Molina H, Allwein B, Kenny TC, Possemato RL, Zhao L, Hite RK, Vinogradova EV, Mansy SS, Birsoy K.
Liu Y, et al.
Science. 2023 Nov 17;382(6672):820-828. doi: 10.1126/science.adf4154. Epub 2023 Nov 2.
Science. 2023.
PMID: 37917749
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Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis.
Shi X, DeCiucis M, Grabinska KA, Kanyo J, Liu A, Lam TT, Shen H.
Shi X, et al.
Mol Cell. 2024 Feb 15;84(4):802-810.e6. doi: 10.1016/j.molcel.2023.12.008. Epub 2023 Dec 28.
Mol Cell. 2024.
PMID: 38157846
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