Bioinformatics analysis identifies DYNC1I1 as prognosis marker in male patients with liver hepatocellular carcinoma

PLoS One. 2021 Oct 22;16(10):e0258797. doi: 10.1371/journal.pone.0258797. eCollection 2021.

Abstract

Background: Liver hepatocellular carcinoma (LIHC) is one of the most common malignant tumors. However, the etiology and exact molecular mechanism of LIHC are still not fully understood, which makes it urgent for us to further study the molecular events behind.

Methods: In this study, differences in mRNA expression between LIHC samples and normal adjacent samples were found through analyzing the TCGA database, and key targets were sought. We analyzed 371 LIHC samples and 50 normal adjacent samples according to P <0.01 and logFC>2.5, a total of 1092 genes were identified differentially expressed, including 995 up-regulated genes and 97 down-regulated genes. We predicted the interactions of these differentially expressed mRNAs, and used Cyto-Hubba to locate the hub gene-dynein cytoplasmic 1 intermediate chain 1 (DYNC1I1).

Results: Survival analysis showed that DYNC1I1 was a prognostic factor for LIHC male patients. Functional enrichment indicated that DYNC1I1 and differentially expressed interacting proteins were involved in the cell cycle.

Conclusion: In conclusion, this study discovers that DYNC1I1 can be used as a prognostic marker for LIHC male patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / genetics*
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / mortality*
  • Case-Control Studies
  • Computational Biology / methods*
  • Cytoplasmic Dyneins / genetics*
  • Databases, Genetic
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Gene Regulatory Networks
  • Humans
  • Liver Neoplasms / genetics
  • Liver Neoplasms / mortality*
  • Male
  • Prognosis
  • Sex Characteristics
  • Survival Analysis

Substances

  • Biomarkers, Tumor
  • DYNC1I1 protein, human
  • Cytoplasmic Dyneins

Grants and funding

This study was funded by the Hubei Province health and family planning scientific research project (WJ2019M257) and Wuhan Municipal Health scientific research project (WX20C13). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.