Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population

Guangzhi Yang; Boshen Wang; Dawei Sun; Huimin Wang; Mengyao Chen; Hao Chen; Baoli Zhu

doi:10.1371/journal.pone.0251090

Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population

PLoS One. 2021 May 11;16(5):e0251090. doi: 10.1371/journal.pone.0251090. eCollection 2021.

Authors

Guangzhi Yang^{1

2}, Boshen Wang¹, Dawei Sun¹, Huimin Wang¹, Mengyao Chen³, Hao Chen³, Baoli Zhu^{1

2}

Affiliations

¹ School of Public Health, Southeast University, Nanjing, Jiangsu, China.
² Department of Prevention and Control for Occupational Disease, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, Jiangsu, China.
³ School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.

Abstract

Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Adolescent
Adult
Aged
Aged, 80 and over
Asian People
China
Female
Genetic Association Studies
Hearing Loss, Noise-Induced / genetics*
Humans
Male
Middle Aged
Noise, Occupational*
Occupational Diseases / genetics*
Polymorphism, Single Nucleotide
Young Adult

Substances

Adaptor Proteins, Signal Transducing
TAB2 protein, human

Grants and funding

ZBL Jiangsu Province’s Outstanding Medical Academic 5 Leader program (CXTDA2017029). ZBL Preventive Medicine Foundation of Jiangsu (Y2015049). ZBL Six Talent Peaks Project in Jiangsu Province(WSW-017). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.