Impaired Peyer's patch development in BOB.1/OBF.1-deficient mice

Eur J Immunol. 2021 Jul;51(7):1860-1863. doi: 10.1002/eji.202048578. Epub 2021 Mar 26.

Abstract

BOB.1/OBF.1 expression regulates the transcription of direct and indirect target genes. We propose that BOB.1/OBF.1 affects CXCL13-CXCR5 signaling of LTinducer and LTorganizer cells during embryonic Peyer's patch organogenesis as well as of B cells and follicular dendritic cells during lymphocyte homing at postnatal stages of secondary lymphoid organ development.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes
  • Chemokine CXCL13 / metabolism
  • Dendritic Cells, Follicular / metabolism
  • Mice
  • Organogenesis / physiology
  • Peyer's Patches / metabolism*
  • Receptors, CXCR5 / metabolism
  • Trans-Activators / deficiency*
  • Trans-Activators / metabolism*

Substances

  • Chemokine CXCL13
  • Pou2af1 protein, mouse
  • Receptors, CXCR5
  • Trans-Activators