Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1390-1407. doi: 10.1161/ATVBAHA.120.315507. Epub 2021 Feb 11.

Hiromi Matsuda^#^{1

2

3}, Yoshiya Ito^#^{1

2}, Kanako Hosono^#^{1

2}, Seri Tsuru^{1

2

3}, Tomoyoshi Inoue¹, Shuji Nakamoto^{1

4}, Chie Kurashige³, Masanori Hirashima⁵, Shuh Narumiya⁴, Hirotsugu Okamoto³, Masataka Majima^{1

2}

¹ Department of Molecular Pharmacology, Graduate School of Medical Sciences (H.M., Y.I., K.H., S.T., T.I., S.N., M.M.), School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
² Department of Pharmacology (H.M., Y.I., K.H., S.T., M.M.), School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
³ Department of Anesthesiology (H.M., S.T., C.K., H.O.), School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
⁴ Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Japan (S.N.).
⁵ Division of Pharmacology, Graduate School of Medical and Dental Sciences, Niigata University, Japan (M.H.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: arachidonic acid; inflammation; lymphangiogenesis; macrophages; thromboxanes.