Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

Elife. 2020 Aug 24:9:e58042. doi: 10.7554/eLife.58042.

Abstract

We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.

Keywords: AMPA receptor; hippocampus; long-term potentiation; memory formation; mouse; neuroscience; rat; spatial learning; synaptic plasticity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Line
  • Female
  • Gene Knock-In Techniques
  • Hippocampus / metabolism
  • Humans
  • Long-Term Potentiation* / genetics
  • Long-Term Potentiation* / physiology
  • Male
  • Maze Learning / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Protein Domains / genetics
  • Receptors, AMPA* / chemistry
  • Receptors, AMPA* / genetics
  • Receptors, AMPA* / metabolism
  • Spatial Memory / physiology

Substances

  • Receptors, AMPA
  • glutamate receptor ionotropic, AMPA 1