Lack of Proteinase 3 Stabilizes Advanced Atherosclerotic Lesions

Thromb Haemost. 2020 Jun;120(6):994-997. doi: 10.1055/s-0040-1710316. Epub 2020 May 13.

Authors

Almudena Ortega-Gomez^{1

2}, Oliver Soehnlein^{1

2

3}

Affiliations

¹ Institute for Cardiovascular Prevention, LMU Munich, Munich, Germany.
² DZHK, Partner site Munich Heart Alliance, Munich, Germany.
³ Department of Physiology and Pharmacology (FyFa), Karolinska Institutet, Stockholm, Sweden.

PMID: 32403136
DOI: 10.1055/s-0040-1710316

No abstract available

MeSH terms

Animals
Aorta / pathology
Atherosclerosis / enzymology*
Atherosclerosis / pathology
Cathepsin G / deficiency
Cathepsin G / physiology
Collagen / analysis
Cytokines / metabolism
Diet, High-Fat / adverse effects
Leukocyte Elastase / deficiency
Leukocyte Elastase / physiology
Mice
Mice, Knockout
Mice, Knockout, ApoE
Plaque, Atherosclerotic / enzymology*
Rupture, Spontaneous
Serine Endopeptidases / deficiency*
Serine Endopeptidases / physiology

Substances

Cytokines
Collagen
Prtn3 protein, mouse
Serine Endopeptidases
Cathepsin G
Ctsg protein, mouse
Elane protein, mouse
Leukocyte Elastase