The emerging roles of WBP2 oncogene in human cancers

Hossein Tabatabaeian; Angad Rao; Alisha Ramos; Tinghine Chu; Marius Sudol; Yoon Pin Lim

doi:10.1038/s41388-020-1318-0

The emerging roles of WBP2 oncogene in human cancers

Oncogene. 2020 Jun;39(24):4621-4635. doi: 10.1038/s41388-020-1318-0. Epub 2020 May 11.

Authors

Hossein Tabatabaeian^{1

2}, Angad Rao², Alisha Ramos², Tinghine Chu^{2

3}, Marius Sudol^{4

5

6}, Yoon Pin Lim^{7

8

9}

Affiliations

¹ Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.
² Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.
³ NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, 117456, Singapore.
⁴ Department of Physiology, National University of Singapore, Mechanobiology Institute, Singapore, 117597, Singapore.
⁵ Institute for Molecular and Cell Biology (IMCB, A*STAR), Singapore, 138673, Singapore.
⁶ Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
⁷ Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore. bchlyp@nus.edu.sg.
⁸ NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, 117456, Singapore. bchlyp@nus.edu.sg.
⁹ National University Cancer Institute, Singapore, 119082, Singapore. bchlyp@nus.edu.sg.

Abstract

WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI₃K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Breast Neoplasms / diagnosis
Breast Neoplasms / genetics
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology
Female
Humans
Oncogene Proteins / genetics
Oncogene Proteins / metabolism*
Trans-Activators / genetics
Trans-Activators / metabolism*

Substances

Oncogene Proteins
Trans-Activators
WBP2 protein, human