The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation

Nat Commun. 2020 Mar 13;11(1):1399. doi: 10.1038/s41467-020-15209-9.

Abstract

Deleted in azoospermia-like (DAZL) is an RNA-binding protein critical for gamete development. In full-grown oocytes, the DAZL protein increases 4-fold during reentry into the meiotic cell cycle. Here, we have investigated the functional significance of this accumulation at a genome-wide level. Depletion of DAZL causes a block in maturation and widespread disruption in the pattern of ribosome loading on maternal transcripts. In addition to decreased translation, DAZL depletion also causes translational activation of a distinct subset of mRNAs both in quiescent and maturing oocytes, a function recapitulated with YFP-3'UTR reporters. DAZL binds to mRNAs whose translation is both repressed and activated during maturation. Injection of recombinant DAZL protein in DAZL-depleted oocytes rescues the translation and maturation to MII. Mutagenesis of putative DAZL-binding sites in these mRNAs mimics the effect of DAZL depletion. These findings demonstrate that DAZL regulates translation of maternal mRNAs, functioning both as the translational repressor and activator during oocyte maturation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding Sites
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Female
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins / metabolism
  • Male
  • Mice / embryology
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Models, Animal
  • Oocytes / metabolism*
  • Oogenesis / genetics*
  • Oogenesis / physiology*
  • Pregnancy Proteins / metabolism
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism*
  • Transcription Factors / metabolism
  • Transcriptome
  • mRNA Cleavage and Polyadenylation Factors

Substances

  • Cell Cycle Proteins
  • Cpeb1 protein, mouse
  • DAZL protein, mouse
  • Homeodomain Proteins
  • Obox5 protein, mouse
  • Oosp1 protein, mouse
  • Pregnancy Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • Transcription Factors
  • mRNA Cleavage and Polyadenylation Factors