Association between ZNF184 and symptoms of Parkinson's disease in southern Chinese

Study objectives: The aim was to investigate the association between ZNF184 and symptoms of Parkinson's disease (PD) in southern Chinese.

Methods: A total of 241 PD patients were recruited in this study. All patients were evaluated by Sniffin' Sticks 16 (SS-16), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson's disease Questionnaire (PDQ-39) and MDS-Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded.

Results: There was association of rapid eye movement sleep behavior disorder (RBD) under additive, dominant and overdominant model (p 0.039, additive; p 0.028, dominant; p 0.044, overdominant). We also found the association of excessive daytime sleepiness under the dominant model, the association of urgent urination or urinary incontinence under the recessive model and the association of sensitive to hot under the overdominant model (excessive daytime sleepiness: p 0.032, dominant; p 0.038, dominant; urgent urination or urgent incontinence: p 0.027, recessive; sensitive to hot: p, 0.027, overdominant).

Conclusions: ZNF184 rs9468199 was associated with the presence of RBD, excessive daytime sleepiness, urgent urination or urgent incontinence and sensitive to hot.