Melanoma-associated retinopathy

Clin Exp Dermatol. 2020 Mar;45(2):147-152. doi: 10.1111/ced.14095. Epub 2019 Nov 19.

Abstract

Melanoma-associated retinopathy (MAR) is a rare paraneoplastic autoimmune manifestation of cutaneous malignant melanoma. Patients classically present with acute onset night blindness, positive visual phenomena and visual field defects, and typically have significantly reduced quality of life as a result. Early recognition of MAR is of prognostic significance as it can precede the diagnosis of primary or metastatic malignant melanoma, and early treatment can lower the risk of irreversible immunological damage to the retinal cells with improved visual outcomes. The focus of our review article is therefore to raise awareness of MAR and present the latest evidence relating to the investigation and management of this condition.

Publication types

  • Review

MeSH terms

  • Humans
  • Immunotherapy*
  • Melanoma / complications*
  • Melanoma / diagnosis
  • Melanoma / surgery
  • Melanoma, Cutaneous Malignant
  • Night Blindness / etiology
  • Night Blindness / therapy
  • Paraneoplastic Syndromes, Ocular / diagnosis*
  • Paraneoplastic Syndromes, Ocular / immunology
  • Paraneoplastic Syndromes, Ocular / therapy
  • Skin Neoplasms / complications*
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / surgery
  • Visual Fields