Brain aromatase modulates cardiac functions in embryonic zebrafish

Zulvikar Syambani Ulhaq

doi:10.1080/23144599.2019.1675287

Brain aromatase modulates cardiac functions in embryonic zebrafish

Int J Vet Sci Med. 2019 Oct 18;7(1):31-34. doi: 10.1080/23144599.2019.1675287. eCollection 2019.

Author

Zulvikar Syambani Ulhaq¹

Affiliation

¹ Department of Biomedical Science, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim Islamic State University of Malang, Batu, Indonesia.

Abstract

Oestradiol (E₂) is known as a female reproductive hormone with pleiotropic effects on the cardiovascular system. Local E₂ biosynthesis such as in the brain and myocardial cells have important physiological and pathophysiological roles. E₂ production is catalysed by aromatase (Aro) enzyme. In teleost, two Aro isoforms are distinctly expressed in the ovary and brain. In this study, the role of brain Aro (AroB) in modulating cardiovascular system is investigated. AroB MO-mediated knockdown decreased ventricular functions. Moreover, embryos injected with AroB MO displays a sign in developing heart failure. All the effects caused by AroB MO were partially reversed by exposure to E₂. Taken together, this study demonstrates the role of AroB in modulating normal cardiovascular function in zebrafish embryos.

Keywords: Brain aromatase; cardiovascular; oestradiol; zebrafish.