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Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation.
Leopold C, Duta-Mare M, Sachdev V, Goeritzer M, Maresch LK, Kolb D, Reicher H, Wagner B, Stojakovic T, Ruelicke T, Haemmerle G, Hoefler G, Sattler W, Kratky D. Leopold C, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr;1864(4):500-511. doi: 10.1016/j.bbalip.2019.01.007. Epub 2019 Jan 9. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30639734 Free PMC article.
Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation.
Pajed L, Wagner C, Taschler U, Schreiber R, Kolleritsch S, Fawzy N, Pototschnig I, Schoiswohl G, Pusch LM, Wieser BI, Vesely P, Hoefler G, Eichmann TO, Zimmermann R, Lass A. Pajed L, et al. J Biol Chem. 2019 Jun 7;294(23):9118-9133. doi: 10.1074/jbc.RA118.007201. Epub 2019 Apr 25. J Biol Chem. 2019. PMID: 31023823 Free PMC article.
Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation.
Wagner C, Hois V, Pajed L, Pusch LM, Wolinski H, Trauner M, Zimmermann R, Taschler U, Lass A. Wagner C, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Aug;1865(8):158730. doi: 10.1016/j.bbalip.2020.158730. Epub 2020 May 1. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32361002 Free PMC article.