A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis

Wei Pan; Shaohua Gong; Yanhua Li; Huiwen Zhang; Na Li; Bo Tang

doi:10.1039/c8cc06796a

A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis

Chem Commun (Camb). 2018 Nov 27;54(95):13439-13442. doi: 10.1039/c8cc06796a.

Authors

Wei Pan¹, Shaohua Gong, Yanhua Li, Huiwen Zhang, Na Li, Bo Tang

Affiliation

¹ College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. lina@sdnu.edu.cn tangb@sdnu.edu.cn.

PMID: 30430148
DOI: 10.1039/c8cc06796a

Abstract

A graphene-based nanocarrier modified with death receptor 4 (DR4) antibody and AKT siRNA has been developed, which can synergistically strengthen death receptor-mediated apoptosis and enhance the cancer therapeutic effect in vivo.

MeSH terms

Animals
Apoptosis*
Drug Carriers / chemistry
Female
Graphite / chemistry
Humans
MCF-7 Cells
Mice
Nanoparticles / chemistry
Neoplasms, Experimental / metabolism
Neoplasms, Experimental / pathology
Proto-Oncogene Proteins c-akt / metabolism*
RNA, Small Interfering / metabolism*
Receptors, TNF-Related Apoptosis-Inducing Ligand / metabolism*

Substances

Drug Carriers
RNA, Small Interfering
Receptors, TNF-Related Apoptosis-Inducing Ligand
TNFRSF10A protein, human
Graphite
Proto-Oncogene Proteins c-akt